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Clinical pharmacology is recognized and serves as the premier discipline at the forefront of the discovery, development, regulation, and use (DDRU) of safe and effective medications necessary for the prevention and treatment of illness.

The Division of Clinical Pharmacology and Experimental Therapeutics at the University of California, San Francisco, has been engaged in these activities since 1965. The Department of Medicine (School of Medicine) and the Department of Bioengineering and Therapeutic Sciences (School of Pharmacy) jointly sponsor the Division. It maintains close ties with other clinical and basic research units of the University, including the Departments of Pharmacology, Pediatrics, Psychiatry, Epidemiology and the Cardiovascular Research Institute.


	Featured Article... Metformin is one of the most widely prescribed drug for the treatment of diabetes. There is considerable individual variability in response to metformin. The Giacomini research group has studied the influence of organic cation transporter 1 (OCT1), which is responsible for uptake of metformin by the liver, where it acts. The Giacomini group, including fellows in the UCSF clinical pharmacology training program, showed that deletion of the OCT1 gene in mice abolishes the glucose-lowering effect of metformin in mice and that the effects of metformin in people who carry genes associated with reduced OCT1 function have a reduced response to metformin. This research helps explain variability in response to metformin and may lead to ways to better individualize treatment for diabetics. read more...

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